Project HarmonicSS

Duration: 2017 - 2020
HARMONIzation and stratification on health care taking on primary Sjögren’s Syndrome (pSS)


pSS is a chronic systemic autoimmune disease characterized by lymphocytic infiltration of exocrine glands and dry eye and mouth manifestations, systemic involvement and an increased risk of evolution into malignant lymphoma, which is the main disease complication. It affects primarily women (9 females / 1 male) after menopause.
Although the cause of pSS is unknown, the disease develops under the influence of a combination of genetic, environmental, and immune factors, as is the case with other autoimmune disorders. Importantly, pSS is relevant not only due to its clinical impact but also as one of the few “model” diseases to link autoimmunity, cancer development (lymphoproliferation) and the pathogenetic role of infection.

Doel Aim

The study aims to the HARMONIzation and integrative analysis of regional, national and international cohorts on primary Sjögren’s Syndrome (pSS) towards improved stratification, treatment and health policy making.


The study of pSS can facilitate research in many areas of medicine. For this reason, the possibility for sustainability and expandability of the platform is enhanced. In addition, pSS has a significant impact on the healthcare systems, similar to that of rheumatoid arthritis. The harmonization, semantic interlinking and the subsequent integration of pSS cohorts foreseen in the HarmonicSS project is highly achievable, based on already shared and internationally-accepted classification criteria and measures of disease activity and damage.

SamenwerkingsverbandProject partners

This project is a collaboration of 35 partners from 13 EU member states. Nivel is ons of the project partners. Coordinating partner is the University of Athens.

Panels met patiënten, cliënten en burgersNivel project team

Participating Nivel researchers in are:


This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 731944.

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Meer wetenWant to know more?

For more information on this project, please feel free to get in touch with the Nivel expert(s) involved. You will find them on the right, together with the (future) Nivel deliverables (publications) and other relevant content. You can also visit the international project website


Verheij, R., Paget, J . Project HarmonicSS. From: [Last update 25-October-2021; consulted on 22-May-2022]. URL: