Publicatie

Publication date

Het influenzaseizoen 2010/2011 in Nederland: het nieuwe A(H1N1)-virus van 2009 blijft actief.

Jong, J.C. de, Donker, G.A., Meijer, A., Hoek, W. van der, Rimmelzwaan, G.F., Osterhaus, A.D.M.E. Het influenzaseizoen 2010/2011 in Nederland: het nieuwe A(H1N1)-virus van 2009 blijft actief. Nederlands Tijdschrift voor Medische Microbiologie: 2011, 19(4), p. 21-27.
Download the PDF
The influenza epidemic of the 2010/11 season was a regular seasonal epidemic showing a lower size and less hospital admissions compared with the 2009 pandemic. Most of the causative viruses were of (sub)type A(H1) pdm09 and B (mainly from the phylogenetic lineage B/ Victoria/2/87). Subtype A(H3) did not play a significant role, in contrast to North America, where it circulated extensively this winter. The A(H1N1)pdm09 virus was detected in 37 fatal cases, as compared with 63 fatalities in the pandemic year 2009. Since the last season, no significant antigenic drift has occurred in any of the four circulating (sub)types of influenza viruses. Except for the isolates of the B/Yamagata/16/88 lineage, the match between the epidemic strains and the vaccine viruses used was good. Among 161 A(H1)-, A(H3)- and B-isolates, one oseltamivir-resistent virus was detected. For the 2011/12 season, WHO has recommended the same vaccine strain composition as for the 2010/11 season, viz.: A(H1N1) pdm09: A/California/7/09, A(H3N2): A/Perth/16/09 and B: B/Brisbane/60/08 of the B/Victoria/2/87 lineage.(aut. ref.)