Mariëtte Hooiveld
Publicatie
Datum
30-11-2024
Influenzaseizoen 2023/2024 in Nederland: een seizoen met vooral A(H1N1)pdm09influenzavirus.
Koel, B., Meijer, A., Hooiveld, M, Lange, M. de, Eggink, D., Koopmans, M., Gageldonk-Lafeber, R. van, Fouchier, R. Influenzaseizoen 2023/2024 in Nederland: een seizoen met vooral A(H1N1)pdm09influenzavirus. Nederlands Tijdschrift voor Medische Microbiologie: 2024. 32(4), p. 176-183
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De griepepidemie van seizoen 2023/2024 begon in week 3 van 2024. Tijdens de negen weken durende epidemie kwam de incidentie van influenza-achtige ziekten (IAZ) slechts vier weken boven het basisniveau voor verhoogde activiteit van IAZ in de huisartsenpraktijk. Ongeveer 70 procent van de onderzochte influenzavirussen uit de verschillende surveillancebronnen behoorde tot subtype A(H1N1)pdm09 en ongeveer 30 procent tot subtype A(H3N2). Influenza B-virussen werden weinig gedetecteerd. De influenza B-virussen waarvoor de lijn werd vastgesteld behoorden alle tot de Victorialijn. Er werden meerdere virussen gedetecteerd die veranderingen hadden op aminozuurposities die mogelijk bijdragen aan antigene variatie. Echter, slechts één A(H1N1)pdm09-virus en drie A(H3N2)-virussen van de 43 geteste influenza A-en B-virussen vertoonden een afwijkend patroon in de hemagglutinatie-remmingstest in vergelijking met frettenantisera opgewekt tegen vaccinstammen. Er werden 34 A(H1N1)pdm09-virussen gevonden met mutaties die duidden op (sterk) verminderde gevoeligheid voor oseltamivir. Mensen die dit seizoen de griepprik kregen hadden 51 procent minder kans op griep.
The 2023/2024 influenza epidemic in the Netherlands started in week 3 of 2024 and continued for nine weeks. During the influenza epidemic, the weekly incidence of patients with influenza-like illness reported by sentinel
general practices was above the threshold for increased activity for four weeks. Approximately 70 per cent of the influenza viruses from all surveillance sources belonged to subtype A(H1N1)pdm09, and about 30 percent to subtype A(H3N2). Influenza B viruses were rarely detected, and all for which the lineage could be determined belonged to the Victoria lineage. Several viruses were detected with changes in amino acid positions that may contribute to antigenic variation. One A(H1N1)pdm09 virus and three A(H3N2) viruses out of the 43 tested influenza A and B viruses showed reduced titers to sera raised against vaccine strains in the hemagglutination inhibition test. Thirtyfour A(H1N1)pdm09 viruses were found with mutations indicating (significantly) reduced sensitivity to oseltamivir. People who were vaccinated against influenza this season were 51 percent less likely to get influenza.
general practices was above the threshold for increased activity for four weeks. Approximately 70 per cent of the influenza viruses from all surveillance sources belonged to subtype A(H1N1)pdm09, and about 30 percent to subtype A(H3N2). Influenza B viruses were rarely detected, and all for which the lineage could be determined belonged to the Victoria lineage. Several viruses were detected with changes in amino acid positions that may contribute to antigenic variation. One A(H1N1)pdm09 virus and three A(H3N2) viruses out of the 43 tested influenza A and B viruses showed reduced titers to sera raised against vaccine strains in the hemagglutination inhibition test. Thirtyfour A(H1N1)pdm09 viruses were found with mutations indicating (significantly) reduced sensitivity to oseltamivir. People who were vaccinated against influenza this season were 51 percent less likely to get influenza.
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