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Publicatie datum

Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications.

Caini, S., Bellerba, F., Corso, F., Díaz-Basabe, A., Natoli, G., Paget, J., Facciotti, F., De Angelis, S.P., Raimondi, S., Palli, D., Mazzarella, L., Pelicci, P.G., Vineis, P., Gandini, S. Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications. Eurosurveillance: 2020, 25(23), 5 p.
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Review
We reviewed the diagnostic accuracy of SARS-CoV-2 serological tests.

Results
Random-effects models yielded a summary sensitivity of 82% for IgM, and 85% for IgG and total antibodies. For specificity, the pooled estimate were 98% for IgM and 99% for IgG and total antibodies. In populations with≤5% of seroconverted individuals, unless the assays have perfect (i.e. 100%) specificity, the positive predictive value would be≤88%. Serological tests should be used for prevalence surveys only in hard-hit areas. (aut. ref.)