Influenza infections: a literature review on the clinical characteristics and severity, 2017

Duration: feb - dec 2017

Two studies carried out by the Centers for Disease Control and Prevention (CDC) and published in 2003 and 2004 found that the number of hospitalizations and deaths differed by virus type and sub-type, with the highest number of hospitalizations and deaths found in seasons when the influenza A(H3N2) was the dominant circulating influenza virus. More recently, several studies that have investigated whether the influenza virus (sub)type has an independent effect on clinical presentation and disease severity have provided conflicting results, mainly due to large heterogeneity of study designs and populations being examined.

Our systematic review of published empirical studies will assess whether we can define differences in the severity of influenza infections for different influenza virus types and sub-types (clinical signs/symptoms, hospitalizations and influenza-related death).

Systematic literature review

Publication in a peer-reviewed journal
Dit project wordt gesubsidieerd door
Sanofi Pasteur, France
Sanofi Pasteur, France