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Cleaning and asthma characteristics in women.
Dumas, O., Siroux, V., Luu, F., Nadif, R., Zock, J.P., Kauffmann, F., Moual, N. le. Cleaning and asthma characteristics in women. American Journal of Industrial Medicine: 2014, 57(3), p. 303-311.
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Background
We aimed to assess the associations between occupational exposure to cleaning products, a gender-related exposure, and asthma characteristics, considering clinical, mmunological and inflammatory aspects.
Methods
Analyses were conducted in 391 women (73 with adult-onset asthma) from the follow-up of the Epidemiological Study on the Genetics and Environment of Asthma (EGEA). Occupational exposure to cleaning/disinfecting products was estimated using the asthma-specific job-exposure-matrix (44 women exposed).
Results
Occupational exposures were associated with more symptomatic asthma (odds ratio (95% CI): 2.8(1.2–6.4)) and severe asthma (5.1(1.7–15.3)). An association was suggested for poorly controlled asthma (2.2(0.9–5.5)). Associations were observed for asthma without positive skin prick test (3.0(1.1–8.3)), with a low IgE level (2.8(1.2–6.2)), and with a low eosinophil count (3.2(1.5–7.1)).
Conclusions
Results strengthen the evidence of a deleterious role of cleaning products in asthma and are consistent with the hypothesis of non-allergic mechanisms in relation to workplace cleaning exposures. (aut. ref.)
We aimed to assess the associations between occupational exposure to cleaning products, a gender-related exposure, and asthma characteristics, considering clinical, mmunological and inflammatory aspects.
Methods
Analyses were conducted in 391 women (73 with adult-onset asthma) from the follow-up of the Epidemiological Study on the Genetics and Environment of Asthma (EGEA). Occupational exposure to cleaning/disinfecting products was estimated using the asthma-specific job-exposure-matrix (44 women exposed).
Results
Occupational exposures were associated with more symptomatic asthma (odds ratio (95% CI): 2.8(1.2–6.4)) and severe asthma (5.1(1.7–15.3)). An association was suggested for poorly controlled asthma (2.2(0.9–5.5)). Associations were observed for asthma without positive skin prick test (3.0(1.1–8.3)), with a low IgE level (2.8(1.2–6.2)), and with a low eosinophil count (3.2(1.5–7.1)).
Conclusions
Results strengthen the evidence of a deleterious role of cleaning products in asthma and are consistent with the hypothesis of non-allergic mechanisms in relation to workplace cleaning exposures. (aut. ref.)
Background
We aimed to assess the associations between occupational exposure to cleaning products, a gender-related exposure, and asthma characteristics, considering clinical, mmunological and inflammatory aspects.
Methods
Analyses were conducted in 391 women (73 with adult-onset asthma) from the follow-up of the Epidemiological Study on the Genetics and Environment of Asthma (EGEA). Occupational exposure to cleaning/disinfecting products was estimated using the asthma-specific job-exposure-matrix (44 women exposed).
Results
Occupational exposures were associated with more symptomatic asthma (odds ratio (95% CI): 2.8(1.2–6.4)) and severe asthma (5.1(1.7–15.3)). An association was suggested for poorly controlled asthma (2.2(0.9–5.5)). Associations were observed for asthma without positive skin prick test (3.0(1.1–8.3)), with a low IgE level (2.8(1.2–6.2)), and with a low eosinophil count (3.2(1.5–7.1)).
Conclusions
Results strengthen the evidence of a deleterious role of cleaning products in asthma and are consistent with the hypothesis of non-allergic mechanisms in relation to workplace cleaning exposures. (aut. ref.)
We aimed to assess the associations between occupational exposure to cleaning products, a gender-related exposure, and asthma characteristics, considering clinical, mmunological and inflammatory aspects.
Methods
Analyses were conducted in 391 women (73 with adult-onset asthma) from the follow-up of the Epidemiological Study on the Genetics and Environment of Asthma (EGEA). Occupational exposure to cleaning/disinfecting products was estimated using the asthma-specific job-exposure-matrix (44 women exposed).
Results
Occupational exposures were associated with more symptomatic asthma (odds ratio (95% CI): 2.8(1.2–6.4)) and severe asthma (5.1(1.7–15.3)). An association was suggested for poorly controlled asthma (2.2(0.9–5.5)). Associations were observed for asthma without positive skin prick test (3.0(1.1–8.3)), with a low IgE level (2.8(1.2–6.2)), and with a low eosinophil count (3.2(1.5–7.1)).
Conclusions
Results strengthen the evidence of a deleterious role of cleaning products in asthma and are consistent with the hypothesis of non-allergic mechanisms in relation to workplace cleaning exposures. (aut. ref.)