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External validation of prognostic models for preeclampsia in a Dutch multicenter prospective cohort.

Lamain-de Ruiter, M., Kwee, A., Naaktgeboren, C.A., Louhanepessy, R.D., Groot, I. de, Evers, I.M., Groenendaal, F., Hering, Y.R., Huisjes, A.J.M., Kirpestein, C., Monincx, W.M., Schielen, P.C.J.I., Zelfde, A. van't, Oirschot, C.M. van, Vankan-Buitelaar, S.A., Vonk, M.A.A.W., Wiegers, T.A., Zwart, J.J., Moons, K.G.M., Franx, A., Koster, M.P.H. External validation of prognostic models for preeclampsia in a Dutch multicenter prospective cohort. Hypertension in Pregnancy: 2019, 38(2), 78-88
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Objective
To perform an external validation of all published prognostic models for first-trimester prediction of the risk of developing preeclampsia (PE).

Methods
Women <14 weeks of pregnancy were recruited in the Netherlands. All systematically identified prognostic models for PE that contained predictors commonly available were eligible for external validation.

Results
3,736 women were included; 87 (2.3%) developed PE. Calibration was poor due to overestimation. Discrimination of 9 models for LO-PE ranged from 0.58 to 0.71 and of 9 models for all PE from 0.55 to 0.75.

Conclusion
Only a few easily applicable prognostic models for all PE showed discrimination above 0.70, which is considered an acceptable performance.