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Influenza virus resistance to oseltamivir: what are the implications?

Fleming, D.M., Elliot, A.J., Meijer, A., Paget, W.J. Influenza virus resistance to oseltamivir: what are the implications? European Journal of Public Health: 2009, 19(3), 238-239

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Surveillance

Findings
- Influenza caused by an oseltamivir-resistant influenza A(H1N1) virus was widespread across Europe during the 2007–08 winter.
- About 25% of A(H1N1) viruses tested in the European Influenza Surveillance Scheme (EISS) were resistant with an H274Y mutation in the neuraminidase glycoprotein.
- Early indications during the 2008–09 season are that a large proportion of circulating A(H1N1) viruses have retained oseltamivir resistance, and that the resistant virus will likely become dominant in the United States but not in Europe.
- Further analyses have indicated that these oseltamivir-resistant A(H1N1) viruses retain sensitivity to zanamivir and the M2 ion channel inhibitors (M2Is). (aut. ref.)