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Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study.

Costas, L., Infante-Rivard, C., Zock, J.P., Tongeren, M. van, Boffetta, P., Cusson, A., Robles, C., Casabonne, D., Benavente, Y., Becker, N., Brennan, P., Foretova, L., Maynadié, M., Staines, A., Nieters, A., Cocco, P., Sanjose, S. de. Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study. British Journal of Cancer: 2015, 112(7), 1251-1256
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Background
Incidence rates of lymphoma are usually higher in men than in women, and oestrogens may protect against lymphoma.

Methods
We evaluated occupational exposure to endocrine disrupting chemicals (EDCs) among 2457 controls and 2178 incident lymphoma cases and subtypes from the European Epilymph study.

Results
Over 30 years of exposure to EDCs compared to no exposure was associated with a 24% increased risk of mature B-cell neoplasms (P-trend=0.02). Associations were observed among men, but not women.

Conclusions
Prolonged occupational exposure to endocrine disruptors seems to be moderately associated with some lymphoma subtypes. (aut. ref.)