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Prevalence of antibiotic-resistant S.aureus among general practice patients.
Donker, G.A., Nys, S., Driessen, C., Deurenberg, R.H., Stobberingh, E.E. Prevalence of antibiotic-resistant S.aureus among general practice patients. European Journal of Public Health: 2006, 16(Suppl. 1) 186. Abstract. 14 th Eupha conference "Politics, Policies and /or the Public's Health", Montreux, 16-18 November 2006.
Background: Worldwide, the prevalence of antibiotic-resistant Staphylococcus aureus is an increasing problem both inside and outside the hospital. As antibiotic prescription by general practitioners is mainly an empiric therapy, actual data on antibiotic resistance of the microorganisms involved are important. The main indications for antibiotic therapy in general practice patients are urinary tract and respiratory tract infections as well as skin infections. As no actual data on antibiotic resistance of S. aureus, the most important causative agent of skin infections, among general practice patients are available, the present study was performed.
Methods: General practitioners (n ¼ 27) all over The Netherlands, 13 of them participating in the sentinel station of the NIVEL send in nasal swabs from ad random patients without infectious
complaints. The swabs were sent to the microbiological laboratory for isolating and identification of S. aureus. The susceptibility to agents commonly used by general practitioners was determined which includes, among others, methicillin, ciprofloxacin, co-trimoxazole, macrolides, mupirocin, and fusidic acid. Results: In total, 2841 swabs were obtained; the mean number of swabs per general practitioner was 105. S. aureus was isolated from 602 swabs (21%). The prevalence of resistance to ciprofloxacin, cotrimoxazole, and macrolides was 0.2, 0, and 6%, respectively. Resistance to methicillin was observed in four isolates. The prevalence of resistance to mupirocin and fusidic acid was 1 and 5%, respectively. Conclusions: The prevalence of S. aureus among general practice patients was 21%, slightly lower than one should expect. The low resistance percentages against most of the agents tested suggest that the increased resistance of S. aureus in hospitals is very likely not due to a reservoir outside the hospital. These results will support general practitioners in their optimal empiric choice for the treatment of a staphylococcal infection in case antibiotic therapy is necessary.(aut. ref.)
Methods: General practitioners (n ¼ 27) all over The Netherlands, 13 of them participating in the sentinel station of the NIVEL send in nasal swabs from ad random patients without infectious
complaints. The swabs were sent to the microbiological laboratory for isolating and identification of S. aureus. The susceptibility to agents commonly used by general practitioners was determined which includes, among others, methicillin, ciprofloxacin, co-trimoxazole, macrolides, mupirocin, and fusidic acid. Results: In total, 2841 swabs were obtained; the mean number of swabs per general practitioner was 105. S. aureus was isolated from 602 swabs (21%). The prevalence of resistance to ciprofloxacin, cotrimoxazole, and macrolides was 0.2, 0, and 6%, respectively. Resistance to methicillin was observed in four isolates. The prevalence of resistance to mupirocin and fusidic acid was 1 and 5%, respectively. Conclusions: The prevalence of S. aureus among general practice patients was 21%, slightly lower than one should expect. The low resistance percentages against most of the agents tested suggest that the increased resistance of S. aureus in hospitals is very likely not due to a reservoir outside the hospital. These results will support general practitioners in their optimal empiric choice for the treatment of a staphylococcal infection in case antibiotic therapy is necessary.(aut. ref.)
Background: Worldwide, the prevalence of antibiotic-resistant Staphylococcus aureus is an increasing problem both inside and outside the hospital. As antibiotic prescription by general practitioners is mainly an empiric therapy, actual data on antibiotic resistance of the microorganisms involved are important. The main indications for antibiotic therapy in general practice patients are urinary tract and respiratory tract infections as well as skin infections. As no actual data on antibiotic resistance of S. aureus, the most important causative agent of skin infections, among general practice patients are available, the present study was performed.
Methods: General practitioners (n ¼ 27) all over The Netherlands, 13 of them participating in the sentinel station of the NIVEL send in nasal swabs from ad random patients without infectious
complaints. The swabs were sent to the microbiological laboratory for isolating and identification of S. aureus. The susceptibility to agents commonly used by general practitioners was determined which includes, among others, methicillin, ciprofloxacin, co-trimoxazole, macrolides, mupirocin, and fusidic acid. Results: In total, 2841 swabs were obtained; the mean number of swabs per general practitioner was 105. S. aureus was isolated from 602 swabs (21%). The prevalence of resistance to ciprofloxacin, cotrimoxazole, and macrolides was 0.2, 0, and 6%, respectively. Resistance to methicillin was observed in four isolates. The prevalence of resistance to mupirocin and fusidic acid was 1 and 5%, respectively. Conclusions: The prevalence of S. aureus among general practice patients was 21%, slightly lower than one should expect. The low resistance percentages against most of the agents tested suggest that the increased resistance of S. aureus in hospitals is very likely not due to a reservoir outside the hospital. These results will support general practitioners in their optimal empiric choice for the treatment of a staphylococcal infection in case antibiotic therapy is necessary.(aut. ref.)
Methods: General practitioners (n ¼ 27) all over The Netherlands, 13 of them participating in the sentinel station of the NIVEL send in nasal swabs from ad random patients without infectious
complaints. The swabs were sent to the microbiological laboratory for isolating and identification of S. aureus. The susceptibility to agents commonly used by general practitioners was determined which includes, among others, methicillin, ciprofloxacin, co-trimoxazole, macrolides, mupirocin, and fusidic acid. Results: In total, 2841 swabs were obtained; the mean number of swabs per general practitioner was 105. S. aureus was isolated from 602 swabs (21%). The prevalence of resistance to ciprofloxacin, cotrimoxazole, and macrolides was 0.2, 0, and 6%, respectively. Resistance to methicillin was observed in four isolates. The prevalence of resistance to mupirocin and fusidic acid was 1 and 5%, respectively. Conclusions: The prevalence of S. aureus among general practice patients was 21%, slightly lower than one should expect. The low resistance percentages against most of the agents tested suggest that the increased resistance of S. aureus in hospitals is very likely not due to a reservoir outside the hospital. These results will support general practitioners in their optimal empiric choice for the treatment of a staphylococcal infection in case antibiotic therapy is necessary.(aut. ref.)
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