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Ankylosing spondylitis: a risk factor for myocardial infarction?

Peters, M.J., Visman, I., Nielen, M.M.J., Dillen, N. van, Verheij, R.A., Horst-Bruinsma, I.E. van der, Dijkmans, B.A., Nurmohamed, M.T. Ankylosing spondylitis: a risk factor for myocardial infarction? Annals of the Rheumatic Diseases: 2010, 69(3), 579-581
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OBJECTIVES: To ascertain the prevalence of myocardial infarction (MI) in ankylosing spondylitis (AS) relative to that in the general population. METHODS: A questionnaire was sent to 593 AS patients, aged between 50 and 75 years and registered at the Jan van Breemen Institute or VU University Medical Centre. A total of 383 (65%) AS patients returned their questionnaire that covered the primary outcome (non-fatal) MI. The prevalence for MI was calculated with data from the general population provided by Netherlands Information Network of General Practice databases as reference. RESULTS: The overall prevalence for MI was 4.4% in AS patients versus 1.2% in the general population, resulting in an age and gender adjusted odds ratio of 3.1 (95%CI: 1.9-5.1) for AS patients. When non-responders (35%) were considered as non-MI the odds ratio decreased to 1.9 (95%CI: 1.2-3.2). CONCLUSIONS: Our observations indicate that the MI prevalence is increased in AS patients. (aut. ref.)